Standings
| Zone | # | Team | P | W | D | L | Goals | GD | Pts | Last 5 |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Philadelphia Union | 34 | 20 | 6 | 8 | 57:35 | +22 | 66 | LLoss WWin WWin WWin LLoss | |
| 2 | FC Cincinnati | 34 | 20 | 5 | 9 | 52:40 | +12 | 65 | WWin WWin DDraw WWin WWin | |
| 3 | Inter Miami | 34 | 19 | 8 | 7 | 81:55 | +26 | 65 | WWin WWin WWin LLoss DDraw | |
| 4 | Charlotte | 34 | 19 | 2 | 13 | 55:46 | +9 | 59 | WWin WWin LLoss LLoss WWin | |
| 5 | New York City FC | 34 | 17 | 5 | 12 | 50:44 | +6 | 56 | LLoss LLoss WWin LLoss WWin | |
| 6 | Nashville SC | 34 | 16 | 6 | 12 | 58:45 | +13 | 54 | LLoss DDraw WWin LLoss LLoss | |
| 7 | Columbus Crew | 34 | 14 | 12 | 8 | 55:51 | +4 | 54 | WWin DDraw LLoss DDraw LLoss | |
| 8 | Chicago Fire | 34 | 15 | 8 | 11 | 68:60 | +8 | 53 | DDraw DDraw WWin WWin WWin | |
| 9 | Orlando City SC | 34 | 14 | 11 | 9 | 63:51 | +12 | 53 | LLoss LLoss DDraw DDraw WWin | |
| 10 | New York Red Bulls | 34 | 12 | 7 | 15 | 48:47 | +1 | 43 | LLoss LLoss LLoss WWin LLoss | |
| 11 | New England Revolution | 34 | 9 | 9 | 16 | 44:51 | -7 | 36 | DDraw LLoss WWin LLoss DDraw | |
| 12 | Toronto FC | 34 | 6 | 14 | 14 | 37:44 | -7 | 32 | WWin LLoss DDraw DDraw DDraw | |
| 13 | CF Montreal | 34 | 6 | 10 | 18 | 34:60 | -26 | 28 | LLoss DDraw WWin LLoss LLoss | |
| 14 | Atlanta United FC | 34 | 5 | 13 | 16 | 38:63 | -25 | 28 | DDraw LLoss LLoss LLoss DDraw | |
| 15 | DC United | 34 | 5 | 11 | 18 | 30:66 | -36 | 26 | DDraw LLoss LLoss LLoss DDraw |
| Zone | # | Team | P | W | D | L | Goals | GD | Pts | Last 5 |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | San Diego | 34 | 19 | 6 | 9 | 64:41 | +23 | 63 | WWin WWin LLoss DDraw LLoss | |
| 2 | Vancouver Whitecaps | 34 | 18 | 9 | 7 | 66:38 | +28 | 63 | LLoss WWin WWin DDraw DDraw | |
| 3 | Los Angeles FC | 34 | 17 | 9 | 8 | 65:40 | +25 | 60 | DDraw LLoss WWin WWin WWin | |
| 4 | Minnesota United FC | 34 | 16 | 10 | 8 | 56:39 | +17 | 58 | LLoss WWin DDraw LLoss WWin | |
| 5 | Seattle Sounders | 34 | 15 | 10 | 9 | 58:48 | +10 | 55 | WWin WWin WWin DDraw LLoss | |
| 6 | Austin | 34 | 13 | 8 | 13 | 37:45 | -8 | 47 | LLoss WWin LLoss LLoss WWin | |
| 7 | FC Dallas | 34 | 11 | 11 | 12 | 52:55 | -3 | 44 | WWin LLoss WWin DDraw WWin | |
| 8 | Portland Timbers | 34 | 11 | 11 | 12 | 41:48 | -7 | 44 | LLoss LLoss DDraw DDraw LLoss | |
| 9 | Real Salt Lake | 34 | 12 | 5 | 17 | 38:49 | -11 | 41 | DDraw LLoss WWin WWin LLoss | |
| 10 | San Jose Earthquakes | 34 | 11 | 8 | 15 | 60:63 | -3 | 41 | WWin LLoss WWin LLoss LLoss | |
| 11 | Colorado Rapids | 34 | 11 | 8 | 15 | 44:56 | -12 | 41 | DDraw LLoss DDraw LLoss WWin | |
| 12 | Houston Dynamo | 34 | 9 | 10 | 15 | 43:56 | -13 | 37 | DDraw LLoss LLoss WWin LLoss | |
| 13 | St. Louis City | 34 | 8 | 8 | 18 | 44:58 | -14 | 32 | DDraw WWin LLoss WWin WWin | |
| 14 | Los Angeles Galaxy | 34 | 7 | 9 | 18 | 46:66 | -20 | 30 | WWin WWin LLoss WWin LLoss | |
| 15 | Sporting Kansas City | 34 | 7 | 7 | 20 | 46:70 | -24 | 28 | DDraw LLoss LLoss LLoss LLoss |
Play-off